| 1. | Together, the macula densa and juxtaglomerular cells comprise the juxtaglomerular complex.
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| 2. | The juxtaglomerular cells are also stimulated to release renin by signaling from the macula densa.
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| 3. | The macula densa serves as the detector, while the glomerulus acts as the effector.
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| 4. | Together, juxtaglomerular cells, extraglomerular mesangial cells and macula densa cells comprise the juxtaglomerular complex.
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| 5. | If less Na + is sensed by the macula densa, renin release by juxtaglomerular cells is increased.
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| 6. | This demonstrates the macula densa feedback, where compensatory mechanisms act in order to return GFR to normal.
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| 7. | The point where DCT contacts the cortical thick ascending limb of the loop of Henle is called macula densa.
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| 8. | The macula densa cell can also increase the blood pressure of the afferent arterioles by decreasing the synthesis of adenosine or ATP.
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| 9. | Hence, a decrease in blood pressure results in less NaCl present at the distal tubule, where the macula densa is located.
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| 10. | Beta blockade, especially of the beta-1 receptor at the macula densa, inhibits renin release, thus decreasing the release of aldosterone.
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